I used to be terrified of cranking my 400d up to 1200ISO or whatever it was... on the 5D im not bothered if im at 3200... 6400 shows slight signs of noise but not enough to ruin a shot
I regularly use ISO 1600 on the 5D classic (with fast glass). Noise isn't such an issue as the loss of sharpness IMO. Still delivers great colour and overall pleasing images though, again IMO.
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