I wouldn't say IS is a reason not to go for the E-450, I don't have it on my D40, and before that I had an E-420 without IS. I'd say the bigger issue os the limited range of accessories for the E system, the cost of 4/3 lenses, the range of 4/3 lenses, and the size of the 4/3 sensor itself. The E-420 is a cracking camera...but I'm glad I moved to Nikon.