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- Dr Ozone
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... Another thing is that I do have a neurological condition which does affect what I can & cannot carry...
First thing I would be doing is work out your limitations then. Whether a 70-300 is better than a 55-250 is irrelevant if it's too heavy. The Canon 70-300 is 630g although it's not very good which means buying a Tamron 70-300 which is 765g (and that came as a surprise). The 55-250 is just over 300g so half the weight although there is a more expensive 55-250 if I recall which had some metal and will therefore be heavier but it was optically the same so I wouldn't bother with it.
Although you got your 450D for free it is perhaps worth investigating whether the mirrorless way is better as you can get a much lighter set up but that depends on just how limiting your condition is.
As for the difference between 250 and 300- not enough to worry about really- http://imaging.nikon.com/lineup/lens/simulator/
Like all things in life, you can get loads of advice but at some point you have to take the plunge and then work out whether it woks for you- this often means you will buy things and then decide it's not quite working as intended- it's inevitable.
If the weight is fine I would pick up a 55-250 for under £100 and leave it as that. I see no need to also buy a 50mm f1.8- you may not take any pictures at that focal length (and you have an 18-55)- you have a need for longer reach- one step at a time surely. A great many people always recommend a 50mm but I could count my pictures on one hand in the 30-70mm range so what's the point in me buying one? Maybe you will need a fast aperture at 85 or 35 or 24- only you can say; save your money until then would be my advice.