"Diffraction" is the size that a point of light/detail is projected onto the sensor. When that point is projected larger than a pixel diffraction is occurring. When it is larger than 2 pixels it is said to be "diffraction limited" and detail/sharpness is lost.
A smaller f-stop (larger #) is one of many things that cause a point of light to be projected larger... that is just the physics of light and nothing is going to change that. So yes, diffraction concerns are the same w/wo tubes. But if the adaptor/filter/etc has glass that can additionally contribute to diffraction (and other optical errors).