OK, so it will autofocus, so long as your camera firmware is v1.2.1 or later. It will only use a relatively small number of autofocus points, however; this may or may not be restrictive for you, depending on how you use the camera.
The other potential issue is image quality. Images will be degraded when you use a 2x Extender. How much depends on what type of Extender, and whether the results are "acceptable" is highly subjective. If you use a Canon Mk III Extender, the image quality should be better than you would achieve by cropping and magnifying the image, but I don't know how much better.