Tubes should work well with a 50mm prime, with better quality than close-up lenses, which tend to be blurry at the edges with lots of colour fringing. Okay for flowers perhaps, but not if edge detail is important.
Close ups are easier with longer lenses though, as you have to get very close with shorter focal lengths to get the magnification.
Very shallow depth of field is another problem, so you need a high f/number which, combined with light loss due to the tubes, means long shutter speeds, when camera shake becomes a problem. That's why ring-flash is popular with macro.