.... I no longer use Topaz anything because I much prefer my installed alternatives.
My base camp RAW converter and local adjustments software, I only shoot RAW, is Capture One (C1) and has been for a long time since Apple stopped developing Aperture. I used to use a 2013 iMac.
If you haven't done so already, check in C1 Preferences that any Topaz listed apps are selected as active plug-ins but I seem to recall that unsatisfactorily some were and some weren't!
The latest version of Capture One is launched today 9th December and it might do what's called a 'Round Robin' trip to and from Topaz but I don't know. Topaz wouldn't load to and from C1 via Photoshop either.
So, my very much preferred alternative and my new workflow is C1 base camp > Edit With... > ON1 2022 NoNoise+Sharpen > Effects > Export to a size recipe > C1 TIFF which has streamlined my workflow and I don't need Photoshop in my post-processing workflow any more.
I don't do any sharpening or noise reduction in Capture One or in any other software because the 2022 ON1 performs both perfectly and much more time efficiently. As I now shoot Olympus m4/3 I stay well away from high ISO settings anyway. ON1 RAW has made a big leap forward with version 2022 and now competes directly with both Capture One and Lightroom.
All these images in my Flickr album (with EXIF shown) are post-processed in my workflow described above, so judge for yourself what you think :
A very small selection of my best efforts with the Olympus flagship supertelephoto zoom lens
www.flickr.com
I won't go back to Topaz and particularly disliked all the tedious and constant updates - It's just an AI vehicle.
HTH