Used one on my 40D and 100-400 no AF, but results here
http://www.talkphotography.co.uk/forums/showthread.php?t=167304
Have tested with the 7D and got AF through Live View, this may also work with the 50D but not tryed myself.

You'll lose AF with any extender/TC. Even if you tape the pins and fool the AF into attempting focus it's pretty useless frankly, and live view focus isn't much help for the kind of things you tend to shoot with a lens like that, eg action of some sort.
Image quality can be okay-ish, if you're stuck, but with a 50D you've got enough resolution to simply crop the image and get much the same result, while retaining good AF performance. Also not ideal, but maybe workable.
When you get to 400mm, you hit a brick wall in practical terms. Everything stacks up against you. The answer is big primes and big money.
You'll lose AF with any extender/TC. Even if you tape the pins and fool the AF into attempting focus it's pretty useless frankly, and live view focus isn't much help for the kind of things you tend to shoot with a lens like that, eg action of some sort.
Image quality can be okay-ish, if you're stuck, but with a 50D you've got enough resolution to simply crop the image and get much the same result, while retaining good AF performance. Also not ideal, but maybe workable.
When you get to 400mm, you hit a brick wall in practical terms. Everything stacks up against you. The answer is big primes and big money.

Cheers Richard
I think I'll hire the TC and decide![]()