
IMO, a DOF calculator is about worthless unless you really know what you are doing/want/need... and you usually don't.
Know that the CoC standard that the calculator uses by default is arguably very outdated and pretty poor... i.e. it is based upon approximately 20/40 vision, it doesn't account for non-standard viewing (on a computer screen), it doesn't account for cropping/composition changes in post, and it definitely doesn't account for pixel peeping high resolution sensor images.
IMO, experience is your best tool... E.g. using your 180-600/6.3 on FF 600/6.3 focused at 60ft the DOF is ~ 1ft (1.12'). From there, if you change the magnification by 2x it changes the DOF by ~ 4x; i.e. doubling the distance to 120ft or zooming out to 300mm results in a DOF of ~ 4ft (4.57'). Or, if you change the f# by 2x it changes the DOF by 2x; i.e. 600/12.7 at 60 ft the DOF is ~ 2ft (2.25').
So, just learn a couple reference distances you are commonly working with and then just SWAG the changes based on their relative effectiveness (magnification is 2x as effective as f# is). I don't usually think about the numbers perse; more just in terms of "enough/not enough." But keep in mind that cropping in post also has the same effect on the DOF/magnification (when displayed at the same size).