I've just bought a Domke F-803 ruggedwear bag.
I am very impressed with it, mostly. It fits my cameras and has lots of room for batteries, charger, leads, sunglasses etc. It isn't huge, you may struggle to get a large dslr with lens in, but it can be done.
There isn't much padding to Domke bags, but you can buy their inserts and also many third party ( read "cheaper" ) inserts are available.
The rugged wear range are proofed against the weather with wax, similar to waxed jackets. But, despite reviews saying they are sticky and slimy, they are not. Mine is dry and looks great.
So, why the "mostly"
Well, they are very expensive, but, I suppose they last a lifetime, so if you like them, you keep them forever.
The catch on the front flap is horrendous, and designed to cut your fingers. It will be replaced with something more user friendly soon.
So apart from that, a big thumbs up for Domke from me.
I also have a Billingham Hadley Pro. Another bag that will last forever, but there is proper padding all round and front flap is easier to undo.
But, I prefer the Domke. It is slim and exactly the right size for what I want.
I do wish that camera bag sellers would show someone wearing the bags they are selling though.
It will save a lot of bag buying and selling till you have the right one! Its a pain buying a bag that, according to measurements, seems ideal, only to find its too small or big and bulky or looks silly over your shoulder!
Allan