I had a good few "crumbs" in a lens I bought along with the camera (both since moved on to new owners), which bugged me after a couple of weeks since acquiring them.
Took the vacuum cleaner to the lens, and that was the end of them.
The connector at the end of the flexible hose was a perfect match for the lens opening, so a good seal was created.
Twisted the barrel to zoom the lens in and out a few times.
Worked an absolute charm and didn't have any issues with the lens afterwards – so if the same was to ever happen in the future, I'd do exactly the same thing again, without a moment's hesitation.