Large Format is an amazing way of working if you accept its limitations. Long lenses end practically at about 300mm for example, which on 5x4 is not very long at all, so if you regularly take long lens landscapes you might not be very happy.
They are pretty slow to set up as well, so it helps if you can previsualise the shot without having to look through a viewfinder. You are also restricted in the number of shots you can effectively carry (think 8-10 for a whole days shooting, which includes bracketing), which can be a plus as a limiting factor, but also means you might experiment less. Travelling also becomes something of a logistical problem, but not one that can't be overcome
Weight wise I dont see that much difference between my 5x7 and 2 lens set up (wooden Deardorff with 90/5.6 and 210/5.6) and my 5dmk2 and 2 lens set up (16-35L and 24-70L). Some of the smaller, light weight 5x4 offerings I could see being lighter
The benefits are big though. Precise control of depth of field and focus (when you know what you're doing, but the learning curve is steep) allows for great creative control. Huge resolution is there if you want it of course, but of more practical use is the buttery smooth tonal graduation
You do have all the logistical problems of film of course, sending film to the lab and waiting for its return, plus scanning or darkroom printing if you're lucky
In the end it's very much a personal preference thing, the same as full frame vs crop, primes vs zooms and HDr vs grads. It is very rewarding though when everything goes right and you get your perfect tranies back in the post