I'm planning to start at 1600 and move upwards. I've seen very successfully images at 3200 and 6400.
A tip about in camera noise reduction I've recently read but not tried is:
"When using noise reduction, an equivalent black frame is being shot. It’s a common misconception that noise reduction works like it does in Photoshop. Black frame noise reduction works by exposing an equivalent shot (using all the same exposure parameters) but with the shutter closed. Then, anything whatsoever that appears in the theoretically black print is noise. This is usually the result of heat in your CMOS or CCD. The camera then subtracts these signal values from your photo.This type of noise reduction is only possible in camera and is far superior to noise reduction using single image algorithms like those found in Photoshop. My advice is to leave the noise reduction on for shooting the Milky Way. If you’re stacking exposures (another form of noise reduction common in astrophotography) then you should leave off in camera noise reduction. Also, if you’re stacking images for longer trails, then also leave it off. But for the most part, leave it on. Your stars, even your faint ones, should be safe."