I would update the BIOS on the current motherboard before you do anything, that will confirm if the issue is hardware or firmware related. The latest version of the BIOS is A05 (it displays it at the same time as the Dell logo on boot-up. The driver can be downloaded here:
http://www.dell.com/support/home/us/en/19/product-support/product/studio-xps-8100/drivers
Backup ALL data and take notes of software before you rebuild, just in case!
Changing a motherboard is straight forward once you've done it a few time, it's not hard but you'll need some new CPU paste, once you remove the CPU fan clean the paste from that and the CPU and apply a thin layer of new paste.
Also take lots of photos from what is in the motherboard, especially little cables, these are the things like the power button, LEDs and case/CPU fans, all are important and if you forget where they came from or which way they were it it's a pain in the arse finding out.
Once you have installed the new motherboard as soon as you power on go into the BIOS (F2 at the Dell logo), in there reset the BIOS. You may need to go through the BIOS and make sure all the settings are correct, this will be making sure the SATA ports are enabled so your hard drives and DVD drivers work.
One final point is to search YouTube before if you are worried, someone is bound to have a video doing this, maybe not the same PC but a PC or a Dell...