it all depends on the style of shot you want and what lens you are using!

I'd shoot it one of 2 ways....fast lens, probably 50mm 1.8 with high ISO settings (and probably b&w) to give grainy, atmospheric images or longer exposure, tripod and low ISO to get some nice smooth, contrasty shots.....its personal preference really.
Pretty difficult to give settings for M, but try just popping it into Aperture Priority to give you an idea of exposure times, then maybe fine tune it in Manual?