Been considering long primes myself. I too don't know where to head at the moment, but I've finally shortened the list to 3 lenses.
Sigma 500mm f/4.5
Canon 500mm f/4 L IS
Sigma 300-800mm f/5.6 (a LOT better than the prime)
First of all you need to consider some aspects. The 500mm for Sigma is handholdable, I know since it's the same weight as my 120-300mm f/2.8. The 800mm or the 300-800mm are two of the heaviest lenses in the market. You'll need to spend a fortune on expensive tripods and heads, there is a huge learning curve for such long lenses and when you chose the place you'll sit, you stay there!
But, the Sigmonster (300-800) has the best kill-zone in the market! It is actually my dream lens to combine with my 120-300 which is considered its little brother. But I think I'll end up with the canon in the end. The reason?
Well you may ask why do I have both the SIgma and the canon in my shortlist. Well, the only reason is cost. I am looking for reasons to justify paying double the money for a lens that delivers almost exactly the same optical results.
I've read a lot of reviews, most of them raving on the merits of the Sigma, regarding optical performanse, built quality, handling. All of them say that the Sigma surpasses the Canon in the aspects that it can, ie the detail, better built, smoother focus ring, smoother tripod collar, better tripod bush etc. But the bottm line is that the Canon is a slightly better optical performer, it has IS, which is the most important factor to consider, and the .5 gain in aperture makes a hell of a difference when it comes to TCs.
So, what you want to consider is this. Spend around £2200 on the Sigma, and have 80% the performance from a £4000 lens? Spend the £4000 on probably the best wildlife lens out there? Or spend around the same for a lens with the best kill-zone in the field, stellar optical performance but difficult to use and carry around and without IS.