I'm using a Kenko 1.4TC with my Sigma 150-500 and it still maintains Autofocus. I'm not sure if Nikon TC's work with this lens, if they do wyou will probably be reduced to manual focus. Sigma's website state you can use Sigma TC's with it, but again hit & miss whether AF will work or not. I do find the Kenko TC will perform well as long as enough light is getting to the camera, AF slows in low light, but I find MF i actually quite easy on the 150-500.