I guess my first significant camera was the Canon EOS 10 with a 35-135 lens, the very first SLR and camera I learnt a great deal about picture taking with.
First camera I ever used was an Olympus Trip my sister owned and lent me, I later got an Olympus AF10.
Nikon FM2, F4s & Hasselblad 500 CM were all money earners for me along with more recent Nikon D300s (gave this to my nephew) & D700.
I worked in a photography shop and saw so many lovely cameras and lenses if I had to choose one camera and lens that I have owned to use for the rest of my life it would most probably be a Nikon FM2 with a 35f2. If it was something I haven't owned but used it would be a Leica M6 with a 35mm Summicron I loved selling those!