I've only just found this 'thread', and what a fascinating read it has been has been.
I have a 5D Mklll, and until now, my longest lens was the EF 703-300L f.4-5.6 IS USM.
As this lens doesn't work with a TC, and I wanted a bit more 'reach', I started looking at longer focal length lenses in the 'not silly money' range.
My first consideration was the Sigma 150-500, but having read many reviews, spoken users of this lens on another forum, and at my camera club, it clearly wasn't going to give me the image quality (IQ) I wanted, at the long-end, when wide-open. So this lens was removed from my 'shopping list'.
My next, and quite a serious consideration, was the Tamron 150-600. Having had the Tamron 70-300 f/4-5.6 Di VC USD, which at the time I used with an EOS 7D, being impressed by both the build quality, and the IQ over most of the range, it even being reasonable at the long-end, the 150-600 seemed very tempting at <£1k.
I read several reviews, which while being quite favourable were, perhaps not unexpectedly on a big zoom like this at less the £1k, critical of the fall off in sharpness at the long-end, if used wide-open (f/6.3). It was said that in order to achieve good sharpness at 600mm, an aperture of f/10 was needed.
Until reading this 'thread', I was unaware of the AF problem, but what I had already read regarding not being able to use the lens wide-open at the long-end, without some degradation in IQ, and needing up stop down to at least f/10 to improve things, caused me to step back and 'take stock' of where I was heading.
My main concern was that with my other lenses being Canon L series (24-105 & 70-300), which are 'pin sharp' wide-open throughout their focal length range, I was not going to be completely happy with anything less. Even less so, if I had spent close to £1k.
If had £5k to spend on a lens, then life would be very simple, but that just isn't going to happen.
So, I canvassed the thoughts of experienced photographers (wildlife and aircraft) on another forum, and eventually whittled it down to what I considered was the most sensible and affordable way forward for me. Primarily, this meant sticking with L Glass, but without spending 'silly money', while retaining the sort of IQ that I was used to.
As result I bought the EF 400mm f/5.6 L USM, to which I intend the add a Canon Series lll 1.4x TC, to give my f/8 at 580mm, when needed. Total cost <£1200 new, with frugal shopping that is.
Yep, I know this lens doesn't have IS, but one very experienced wildlife photographer, who has used a variety of long lenses, says the vast majority of his 'keepers' at these long focal lengths, are those taken with the IS switched off. Another guy, who uses the non-IS EF 400mm f/5.6 L, plus 1.4x TC, posted some images taken hand-held in woodland, with this set-up, and they were 'pin sharp.
Of course, you are going to have to use a shutter speed, of at least equal that of the focal length, which means upping the ISO accordingly. However, with the 5D Mklll, that isn't an issue, as it's high ISO low noise performance is excellent.
Having read through this 'thread', I have to say that I am now even more comfortable with my choice.
I sincerely hope that Tamron resolve the AF issue, as I'm sure they will, and that the dust problem experienced is a one-off, and not inherent in the design.
Dave