50mm f/1.8 x3= 150mm f/5.4
Will there be any noticeable difference in sharpness? Almost certainly, quite a lot. A 3x TC isn't going to shine optically even with a pro lens - there's a reason the camera manufacturers don't make 3x TCs. And that's a budget lens which isn't intended to be used with a TC. It should work, but it might not be pretty.