I have the slightly older Wacom Bamboo (smallest one, they have a newer one out now) and it's a brilliant piece of kit. The wireless and batteryless pen is wonderful, and you can set what the two buttons on it do (I have mine set to scroll and right-click). It works great on a single screen, and if I had only one screen I would not hesitate to splash the cash on some of their higher end models, which also include multi-touch finger gestures like Apple's trackpads. However, I have an external monitor plugged into my MacBook when it's on my desk (the only time I'd use a tablet) and Wacom only let you map the tablet over your total screen space. This means that half the tablet area is taken up by one screen, and the other half of it the other screen. As you can probably tell, this isn't great as it effectively halves your horizontal resolution/accuracy and makes it almost impossible to work. There are some patches you can download that let you map it only to one screen, or one screen at a time with a key-press to move it between screens, but I haven't managed to get them working successfully yet. I'm quite happy with my trackpad so I stick to that.