I just tested it, and while there may be something in the theory, in practise there is no significant time difference between pre-flash and main flash delay, when fired using a hard-wired remote flash cable, and wireless. I don't have a radio TTL trigger to hand, so the test was done using optical wireless mastering. I doubt there would be any difference with radio.
For interest, I can also say with a fair degree of accuracy that the delay between the pre-flash and main flash is pretty close to 1/15sec. That's with a Canon 5D2 that has a fairly sluggish shutter, with 580EX flash. It may vary by camera and by brand. Just thinking about how this all works, the electronics side of things happens very swiftly and it's probably the mechanical delays (mirror rising, shutter opening fully) that accounts for the delay.
Edit: I believe that the average person's reaction time is about 1/20sec. I know mine is close to that, which is enough time for someone to have their eyes at least half closed if they react to the pre-flash.