If you 'know what you are doing' then the use of spot metering in full manual and selecting the important tone that you want 'perfect' and you understand how to adjust the exposure to put that tone where it needs to be in the final image then yes the metering mode you choose will make a difference, but if you do not know then it probably will either not make a difference or make things worse.
Important tones:
Skin: very Black -1 to -1.5 stops, Black -2/3rds to -1 stop, Asian 0 (as reading), Caucasian +1/2 to +2/3rds stops, Albino +1 to +1 1/3 stops.
Other Tones: Green Grass, Blue Sky (90 degrees to sun), Red Pillar Box, Light Tarmac All as metered.
Then there are the 2 most important tones:
The brightest part of the image in which you wish to retain texture +2 to +2.5 stops.
The darkest part of the image in which you wish to retain texture -2 to -2.5 stops.
Read this: