I would think it better to shoot at full resolution then reduce during export from LR/PS/etc for whatever purpose, rather than start with a poorer image. I always shoot full res, and upload to Flickr in that, then link from TP, but if loading direct up to TP or to another app/site, I export at the required size, so by changing the longest edge to 1024px for example, file size usually comes down massively, and I can then just tweak it under our 500kb limit using the quality of jpg slider in export.