From a personal perspective, I used MF SLRs for donkey's years and it was quite straightforward. Of course, the cameras and lenses were designed for MF which makes a big difference. Crop DSLRs are miserable in this context, with small, rather dim, viewfinders compared with the big, bright, ones in the SLRs. Full frame makes things a bit easier, but it's not the same as using a MF SLR.
Another point to bear in mind is the lenses. Most of the 'standard' lenses for the old SLRs were quite fast (f1.4, f1.8 and f2.0), fixed focal length and had a long, smooth, focus throw. The 'standard' lens for consumer DSLRs tends to be a short, comparatively slow, zoom which doesn't have the same ability to transmit light. Couple this with a small viewfinder and the result isn't great...
Fortunately, the F2 and its lenses don't suffer from any of these shortcomings!